Melatonin is the primary chronobiotic hormone secreted by the pineal gland that regulates the circadian rhythm and sleep-wake cycle. As a supplement it is the most clinically studied natural sleep ingredient, with robust evidence for jet lag correction, shift work sleep disorder, insomnia onset reduction, and chronobiotic resynchronisation. It is also a potent antioxidant that accumulates in the mitochondria, offering cytoprotective effects beyond its sleep-regulating role.
Applications:
- Sleep onset and insomnia management supplement formulations
- Jet lag and circadian rhythm resynchronisation products
- Shift work sleep disorder management supplements
- Antioxidant and mitochondrial protection formulations
Key Features & Benefits:
- Most clinically studied natural sleep ingredient — hundreds of RCTs
- Reduces sleep onset latency and improves sleep architecture
- Potent mitochondrial antioxidant — cytoprotective beyond sleep
- No animal substance – halal-certified
- Effective at low doses (0.5–3mg) — no morning grogginess
