Allantoin is a cosmetic active ingredient offered by FC Materials, Penang, to cosmetic and personal-care manufacturers.
INCI name: Allantoin
About allantoin
Allantoin (INCI: Allantoin; CAS 97-59-6) is the compound (2,5-dioxoimidazolidin-4-yl)urea, also called 5-ureidohydantoin or glyoxyldiureide. Its molecular formula is C4H6N4O3 and its molecular weight is 158.12.
What it does in a formula
In cosmetic ingredient classifications, allantoin is listed as a soothing agent. In the United States it is also a permitted active ingredient in over-the-counter skin protectant drug products at 0.5 to 2 percent (21 CFR 347.10). That is a US drug-product rule; cosmetic use is regulated separately in each market, so confirm the rules for every market you sell into.
Solubility is the main formulation constraint
Allantoin dissolves poorly. Published values at 25 °C are about 0.57% in water, 0.04% in ethanol (96%), 0.40% in propylene glycol/water (1:1) and 0.60% in glycerol/water (1:1). Above its solubility it will not dissolve in the water phase, so plan the level and the phase with these figures in mind. It melts with decomposition at about 230–239 °C.
What to ask for on the certificate of analysis
- Assay and identification.
- Appearance.
- Melting range.
- Loss on drying.
- Heavy metals.
- Microbiological profile for leave-on products.
Frequently asked questions
Is allantoin soluble in water? Only slightly: about 0.57% at 25 °C.
Can I get a specification, COA and SDS? Yes. Ask us with your application and quantity and we will send the documents for the grade we can supply.
More skin-care actives: Cosmetic Actives · all personal care and cosmetic ingredients.
Ask us for
- Specification or technical data sheet
- Certificate of analysis
- Safety data sheet
- Recommended use level
Contact us for halal status, pack size, minimum order and lead time.
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